Safety Form
1.
Are you planning to do any of the activities listed below?
a.
Using organisms from Risk Group 3 or 4
b.
Using parts from an organism in Risk Group 4
c.
Releasing or deploying a genetically modified organism outside the lab
d.
Testing your product on humans (including yourselves)
Yes.
No, we're not planning to do any prohibited activities.
2.
Please read over iGEM’s
White List
.
（https://responsibility.igem.org/guidance/white-list）
Will your team use any organisms or parts not on the whitelist, or do any activities not on the whitelist?
Yes
No, all our work is covered by the White List.
3.
Are you planning to do any of the activities mentioned above that require advance permission from iGEM?
a.
Working with animals or samples from animals (in iGEM, “animals” are vertebrates, like rats or fish, and higher-order invertebrates, like octopus and bees)
b.
Bringing a product of a genetically modified organism outside the lab
c.
Conducting laboratory experiments using human samples, such as blood, DNA, other bodily specimens, and health or psychological outcomes
d.
Using parts or organisms obtained from anywhere other than a trusted commercial or institutional supplier
e.
Biasing the inheritance frequency of a genetic marker in an organism’s progeny, i.e. creating a gene drive
f.
Increasing risks from antimicrobial resistance, such as by using novel resistance factors
Yes
No, we are not doing any of the kinds of work outlined above
4.
Are you collecting any data about people, such as their opinions, quotations, medical history, gender, behavior, attitudes, or concerns?
(
For good reasons, many countries require formal approval for Human Subjects Research, as well as consent procedures for participants. You may need formal permission from a Research Ethics Committee, Institutional Research Board, or equivalent. Remember compliance with relevant laws and regulations is a requirement for participation in iGEM.)
Yes, and we have obtained formal / institutional approval for our work (or will obtain it before starting data collection)
Yes, and we have confirmed that relevant laws, regulations, and institutional rules do not require us to get formal approval
Yes, but we’re unsure if we need formal approval (please read the human subjects research policy)
No, we are not doing surveys, interviews, or other human subjects research
5.
Does your project involve lab work and your team has plans to access lab space?
Yes, our project involves lab work.
No, we will not be accessing a lab space.
6.
Please upload a photo or two of your lab showing the relevant safety features. Available file formats: .png, .jpg, .webp
选择文件
7.
What is the biosafety level of your work space?
Level 1 – standard microbiological lab
Level 2 – moderate containment
Level 3 – high containment
Level 4 – extremely high containment
We have several different lab spaces with different biosafety Levels
Other
8.
Which work areas will you use / are you using to handle biological materials?
Open bench
Biosafety cabinet
Specialist greenhouse
Specialist animal house
Specialist insect facility
Chemical fume hood
Unknown
Other
9.
Describe the goal of your project: what is your engineered organism (or other synthetic biology product, system, or tool) supposed to do?
Good example answers:
-Our bacteria will be engineered to interact with human cells. They will detect tumor cells that express biomarkers for liver cancer. They will use invasin to enter the tumor cells, and then secrete apoptin to kill the tumor cells.
-Our algae will receive gases high in CO2. We will increase their expression of Photosystem II proteins to make them absorb more CO2 from the gas.
10.
Will you be engineering whole organisms, including viruses and cell lines in your project?
Yes
No
11.
Please explain in more detail how your project will be conducted without engineering an organism.
12.
Will you use any other organisms in your project? List organisms, including genus, species, and strain.
13.
As part of your project, are you planning to make / have made new parts or substantively changed existing parts in the Registry?
Yes
No, our project will only use genetic parts that are already in the registry
14.
Could any of your parts be hazardous on their own and/or in the context of your project?
Yes
No
15.
What experiments will you do with your organisms and parts?
Example answers:
-Our bacteria is meant to live on plant leaves, so we will test them on tobacco (Nicotiana benthamiana) in a lab greenhouse.
-We want to use a protein from ants, but its sequence is unknown. So we will capture ants (Camponotus spp.) to extract DNA and RNA to find the sequence of the protein we want.
-Our bacteria need to interact with human cells for a medical application. We will test them in human cell culture using the HEK293 cell line.
-We are interested in a RNA-binding protein expressed in Kluyveromyces lactis. We have found the sequence in a paper and will have it synthesized by a commercial provider.
-Our project will not involve experiments with organisms or parts. We will run digital directed evolution experiments to identify a candidate receptor binding protein for our fungicide.
16.
Are you using some kind of hazardous chemicals in your project?
Yes
No
17.
What kinds of chemicals are you using in your project?
Heavy metals
Carcinogens
Mutagens
Highly flammable chemicals
Acids and corrosive chemicals
Other controlled chemicals (e.g. explosives, psychoactives)
Other hazardous chemicals
18.
If you selected any of the hazardous kinds of chemicals above, please list the specific chemicals you are using.
19.
Is your team using or planning to use an Artificial Intelligence (AI) tool(s) for the development of your project?
Yes
No
20.
Which category of AI tool(s) are you using or planning to use for your project?
Large Language Models
Genetic Prediction Tools
Genetic Design Tools
Protein Structure Prediction Tools
Protein Design Tools
Experimental Design
Lab Automation
Data Analysis
Other
21.
What risks, if any, do you foresee arising from the use of these AI tools in your project? What measures will you take to identify and mitigate these risks?
22.
Are there any hazards presented by the organisms, parts, chemicals, or experiments you described in Q9-21?
Yes
No
23.
Imagine that, in the future, your project was fully developed into a real product that real people could use. How would people use it?
Our project is foundational / we do not have a specific real-world application in mind (e.g. library of standardized promoters, system for communication between cells)
Only digital or non-biological products (e.g. software to model directed evolution experiments, ethical and policy recommendations)
Only in the lab (e.g. reporter strain for measuring the strength of promoters)
In a factory or other industrial manufacturing context (e.g. cells that make a flavor chemical for food, cells that make biofuel)
In a consumer product that ordinary people buy (e.g. cells that clean your clothes, bread made with engineered yeast)
In agriculture / on a farm (e.g. cells that guard against pests, engineered rice plants, cells that promote growth of crop plants)
In a small enclosed device (e.g. a bio-sensing strip with cells that detect arsenic, a paper-based cell-free diagnostic)
In the natural environment (e.g. cells that remove pollution from lakes, engineered forest trees that can resist drought)
To be used in the human body, or in food (e.g. anti-cancer bacteria, bread made with engineered yeast, engineered rice plants)
Other (e.g. bacteria that live on Mars)
24.
Please describe how your project would be used in the real world.
25.
If you were permitted, would the continued development of your project require release beyond containment?
Yes, open release in the environment (e.g. environmental bioremediation)
Yes, release into a human or animal body (e.g. living therapeutic)
Yes, semi-contained release (e.g. cell-based biosensor in a small device)
Yes, release to a non-laboratory contained environment (e.g. wastewater treatment plant)
Yes, release of a product of synthetic biology, but not any living organisms (e.g. biosynthetic fragrance, cell-free diagnostic)
No, the future development of my project would not require release beyond containment
26.
Briefly, describe what experiments, tests, or final uses would need to take place outside of laboratory containment. Include any institutional approval processes or national regulations that you are aware you would need to comply with.
(1-3 sentences)
27. Have people on your team had a conversation (within your team or with someone outside the team) about how any of the bad outcomes below might relate to your project?
Harm to human health and safety
Harm to agricultural animals, crops, or domesticated animals
Harm to materials, equipment, and infrastructure
Harm to the environment, including wild plants and animals
Reducing global, national or health security
Creating or reinforcing of social inequities
Breaking norms about engineering biology
28.
Considering the future use(s) and conversations from the previous questions, do you think your project could potentially lead to any of the bad outcomes listed above?
Yes
No
29.
If your project were fully developed, could any of your engineered organisms or parts spread autonomously in the environment?
Yes, autonomous environmental spread of one or more of our organisms or parts is possible
No, our engineered organisms or parts are unable to spread in the environment
No, we use biocontainment strategies (e.g. kill switches, auxotrophy) to prevent spread (please briefly note these strategies and why you chose them)
No, our project does not involve engineered organisms or parts
Other
30.
Describe these strategies and why you chose them
31. Please select which cohort you belong to.
ZJU-China 2026 WW1
ZJU-China 2026 WW2
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